Meal-Level Modulation in Metabolic Care Settings
Structured, non-systemic metabolic support designed for defined patient profiles and care phases.
SIGRID’s products, powered by patented SiPore® technology, can be incorporated into structured metabolic nutrition workflows across weight management, glycemic balance, hormonal transitions, and long-term metabolic stability.
These structured use frameworks are designed to complement lifestyle strategies and, where relevant, physician-directed care plans.
A Structured Practice Framework
All structured use cases follow a consistent framework built around patient phenotype, care phase, and metabolic objective.
Identify the Patient Profile
Defined metabolic phenotype such as central adiposity, post-meal glucose variability, GLP-1 taper, or hormone-related instability.
Implement Structured Meal-Level Modulation
Targeted post-meal support during defined care windows, typically 3–6 months.
Transition to Maintenance
Lower-frequency use or shift to lighter daily support depending on patient goals and stability.
Core Structured Use Cases
The following structured applications are available to registered practitioners. Below is a high-level overview.
Weight-Loss Protocol
Lean-Mass–Preserving Fat Reduction
Designed for individuals with overweight or obesity, high appetite, and central adiposity.
SiPore® supports stronger per-meal modulation during active fat-loss phases, supporting satiety and sustained metabolic improvements.
Post-GLP-1 Taper Protocol
Rebound Prevention and Appetite Stabilization
For individuals tapering semaglutide or tirzepatide and seeking structured meal-level support.
SiPore® provides structured meal-level modulation to support balanced appetite dynamics and post-meal glucose patterns during transition phases.
Pre-Diabetic A1C-Lowering Protocol
Targeted Glycemic Stabilization
For individuals with elevated A1C within non-diagnostic ranges or impaired glucose regulation.
SiPore® supports moderation of post-meal metabolic load and balanced glycemic patterns over structured use periods.
Menopause Metabolic Stability Protocol
Abdominal Fat and Energy Regulation
For women experiencing metabolic shifts, abdominal fat gain, and increased cravings.
Meal-level modulation supports steadier energy delivery and appetite regulation during hormonal transitions.
PCOS Weight & Glucose Management Protocol
Insulin-Sensitive Metabolic Support
For women with insulin resistance patterns, elevated appetite, and central fat accumulation.
SiPore® supports appetite control and post-meal metabolic balance within broader nutrition strategies.
Postpartum Metabolic Reset
Gradual Recovery and Appetite Recalibration
For women experiencing postpartum metabolic shifts, weight retention, fatigue, and cravings.
A flexible framework may begin with SiPore® for daily metabolic support and incorporate Carb Fence during higher metabolic-load meals.
For women who are pregnant or breastfeeding, use should be evaluated in consultation with a healthcare professional.
Longevity & Healthy Aging Protocol
Daily Metabolic Stability
For adults prioritizing metabolic resilience and healthy aging.
SiPore® provides ongoing meal-level support to help maintain stable energy patterns and reduce cumulative metabolic load over time.
Designed for Practice Integration
Structured use frameworks are designed to fit within standard consultation cadence.
Step 1 – Assessment
Identify metabolic phenotype, appetite pattern, and post-meal variability.
Step 2 – Structured Use Phase
Defined use window, typically 3–6 months depending on patient profile and goals.
Step 3 – Monitoring
Track waist circumference, appetite patterns, post-meal variability, and energy stability.
Step 4 – Maintenance or Transition
Reduce frequency or shift to lighter daily support once stability is achieved.
Full Structured Protocols Available to Registered Practitioners
Detailed frameworks include:
- Dosing and duration guidance
- Escalation and step-down pathways
- Monitoring frameworks
- Lifestyle integration recommendations
- Patient selection criteria
- Scientific rationale and evidence mapping
Access is granted through the Early Access Program.
Mechanism-Led. Scientifically Evaluated. Structurally Applied.
Clinical evaluations of the SiPore® technology have shown:
- Mechanistic enzyme modulation in the small intestine
- Demonstrated reduction in post-prandial glucose spikes
- Evaluated metabolic markers in controlled studies
- Favorable safety and tolerability profile
- Fat loss with lean-mass preservation
Explore full scientific validation on the Science page.
