SiPore® Science | Mechanism-Led, Clinically Evaluated Metabolic Support

Mechanism-Led. Clinically Evaluated.

SiPore® is a non-systemic, gut-local technology designed to reduce per-meal metabolic load through selective enzyme entrapment.

Backed by preclinical research and multiple human studies, SiPore® has demonstrated safety, tolerability, and meaningful modulation of metabolic markers.

In collaboration with leading institutions

SiPore®: A Gut-Local Platform for Metabolic Health

SiPore® is a patented, precision-engineered mesoporous silica material with a precisely engineered pore structure.

When taken orally with meals, it acts locally in the gastrointestinal tract. It is not absorbed systemically.

Its function is mechanical and selective. The pores physically entrap a portion of digestive enzymes involved in carbohydrate and fat digestion (including alpha-amylase and lipase).

This results in partial, localized modulation of digestion at the time of the meal.

Localized Enzyme Entrapment in the Small Intestine

Step 1: Selective Enzyme Entrapment
SiPore® particles mix with food during digestion and physically entrap a portion of alpha-amylase and lipase within their engineered pores.

Step 2: Reduction of Carbohydrate and Fat Breakdown
Reduced enzyme availability leads to slower digestion and more gradual nutrient release into the bloodstream.

Step 3: Lower Post-Meal Metabolic Load
Each meal delivers a reduced metabolic impact, supporting balanced post-meal physiology.

Moderated Post-Meal Glucose and Lipid Response

Slower digestion contributes to lower post-meal fluctuations.

Satiety Support

More gradual nutrient absorption supports prolonged satiety and reduced between-meal snacking.

Reduced Caloric Uptake

A portion of carbohydrates and fats remain unabsorbed and are naturally excreted.

Non-Systemic Action

SiPore® is not absorbed into circulation and does not exert systemic pharmacologic effects.

Well Tolerated. Non-Systemic.

Unlike pharmaceutical lipase inhibitors or carbohydrate blockers, SiPore® does not inhibit digestion.

Because fats are absorbed and retained within the porous silica structure, unabsorbed lipids are not freely released into the stool.

In the pivotal SHINE clinical trial:
- No product-related serious adverse events were reported
- No oily discharge was observed
- No clinically relevant changes in blood counts, liver function, or renal markers were identified

The mechanism enables controlled, physiologically aligned modulation of nutrient digestion without disrupting normal digestive function.